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Adrenocortical tumor, somatic

MedGen UID:
864829
•Concept ID:
C4016392
•
Neoplastic Process
Synonym: Adrenal cortical tumor, somatic
 
OMIM®: 188830

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
A Gene-Based Classification of Primary Adrenocortical Hyperplasias.
Hannah-Shmouni F, Stratakis CA
Horm Metab Res 2020 Mar;52(3):133-141. Epub 2020 Mar 25 doi: 10.1055/a-1107-2972. PMID: 32215884

Recent clinical studies

Etiology

Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical Therapy.
Guan Y, Yue S, Chen Y, Pan Y, An L, Du H, Liang C
Cells 2022 Nov 26;11(23) doi: 10.3390/cells11233784. PMID: 36497046Free PMC Article
Disorders of the adrenal cortex: Genetic and molecular aspects.
Pitsava G, Maria AG, Faucz FR
Front Endocrinol (Lausanne) 2022;13:931389. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.931389. PMID: 36105398Free PMC Article
Genomic classification of benign adrenocortical lesions.
Faillot S, Foulonneau T, Néou M, Espiard S, Garinet S, Vaczlavik A, Jouinot A, Rondof W, Septier A, Drougat L, Hécale-Perlemoine K, Ragazzon B, Rizk-Rabin M, Sibony M, Bonnet-Serrano F, Guibourdenche J, Libé R, Groussin L, Dousset B, de Reyniès A, Bertherat J, Assié G
Endocr Relat Cancer 2021 Jan;28(1):79-95. doi: 10.1530/ERC-20-0128. PMID: 33151900
A Gene-Based Classification of Primary Adrenocortical Hyperplasias.
Hannah-Shmouni F, Stratakis CA
Horm Metab Res 2020 Mar;52(3):133-141. Epub 2020 Mar 25 doi: 10.1055/a-1107-2972. PMID: 32215884
cAMP signaling in cortisol-producing adrenal adenoma.
Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Eur J Endocrinol 2015 Oct;173(4):M99-106. Epub 2015 Jul 2 doi: 10.1530/EJE-15-0353. PMID: 26139209

Diagnosis

Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical Therapy.
Guan Y, Yue S, Chen Y, Pan Y, An L, Du H, Liang C
Cells 2022 Nov 26;11(23) doi: 10.3390/cells11233784. PMID: 36497046Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
A Gene-Based Classification of Primary Adrenocortical Hyperplasias.
Hannah-Shmouni F, Stratakis CA
Horm Metab Res 2020 Mar;52(3):133-141. Epub 2020 Mar 25 doi: 10.1055/a-1107-2972. PMID: 32215884
Genetics of primary macronodular adrenal hyperplasia.
Candida Barisson Villares Fragoso M, Pontes Cavalcante I, Meneses Ferreira A, Marinho de Paula Mariani B, Ferini Pacicco Lotfi C
Presse Med 2018 Jul-Aug;47(7-8 Pt 2):e139-e149. Epub 2018 Jul 31 doi: 10.1016/j.lpm.2018.07.002. PMID: 30075949
Primary bilateral macronodular adrenal hyperplasia.
De Venanzi A, Alencar GA, Bourdeau I, Fragoso MC, Lacroix A
Curr Opin Endocrinol Diabetes Obes 2014 Jun;21(3):177-84. doi: 10.1097/MED.0000000000000061. PMID: 24739311

Therapy

Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical Therapy.
Guan Y, Yue S, Chen Y, Pan Y, An L, Du H, Liang C
Cells 2022 Nov 26;11(23) doi: 10.3390/cells11233784. PMID: 36497046Free PMC Article
Tumor mutational burden presents limiting effects on predicting the efficacy of immune checkpoint inhibitors and prognostic assessment in adrenocortical carcinoma.
Xu F, Guan Y, Zhang P, Xue L, Ma Y, Gao M, Chong T, Ren BC
BMC Endocr Disord 2022 May 14;22(1):130. doi: 10.1186/s12902-022-01017-3. PMID: 35568842Free PMC Article
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517
Mechanisms of disease: adrenocortical tumors--molecular advances and clinical perspectives.
Bertherat J, Groussin L, Bertagna X
Nat Clin Pract Endocrinol Metab 2006 Nov;2(11):632-41. doi: 10.1038/ncpendmet0321. PMID: 17082810

Prognosis

Advances in translational research of the rare cancer type adrenocortical carcinoma.
Ghosh C, Hu J, Kebebew E
Nat Rev Cancer 2023 Dec;23(12):805-824. Epub 2023 Oct 19 doi: 10.1038/s41568-023-00623-0. PMID: 37857840
Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical Therapy.
Guan Y, Yue S, Chen Y, Pan Y, An L, Du H, Liang C
Cells 2022 Nov 26;11(23) doi: 10.3390/cells11233784. PMID: 36497046Free PMC Article
Disorders of the adrenal cortex: Genetic and molecular aspects.
Pitsava G, Maria AG, Faucz FR
Front Endocrinol (Lausanne) 2022;13:931389. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.931389. PMID: 36105398Free PMC Article
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

Clinical prediction guides

Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome.
Santana LS, Guimaraes AG, Almeida MQ
Front Endocrinol (Lausanne) 2022;13:927669. Epub 2022 Jun 23 doi: 10.3389/fendo.2022.927669. PMID: 35813615Free PMC Article
Mutational landscape of non-functional adrenocortical adenomas.
Wu L, Xie J, Qi Y, Su T, Jiang L, Zhou W, Jiang Y, Zhang C, Zhong X, Cao Y, Wang W
Endocr Relat Cancer 2022 Sep 1;29(9):521-532. Epub 2022 Jul 19 doi: 10.1530/ERC-21-0410. PMID: 35731037
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517
Adrenocortical cancer: pathophysiology and clinical management.
Libè R, Fratticci A, Bertherat J
Endocr Relat Cancer 2007 Mar;14(1):13-28. doi: 10.1677/erc.1.01130. PMID: 17395972

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